SHOULDER
NanoFx Microfracture System
The NanoFx® (Nanofracture®) system consists of a reusable hand instrument and a single-use disposable PleuriStik™ k-wire used to perform a microfracture procedure for the treatment of small, localized articular cartilage defect sites. The 1mm PleuriStik disrupts less surface area than a standard microfracture technique and was purposefully designed to reduce damage to the subchondral plate. It penetrates down to a standardized 9mm depth to reach the targeted marrow cells, three times deeper than comparable microfracture techniques.
When tested against an awl or generic k-wire, NanoFx resulted in thin, fragmented cancellous bone channels without rotational heat generation. It also demonstrated deep cancellous bone perforation with a higher number of open trabecular channels.
The NanoFx handle is available with a 15° angle and as an A-Curve, specifically designed for hard to access ankle lesions.
Key Features & Benefits:
- Disposable, always sharp 1mm PleuriStik with reusable targeting handle is an easy-to-use cell delivery system that disrupts less surface area than a standard microfracture technique, reducing damage to the subchondral plate
- Standardized 9mm perforation depth provides improved access to the targeted marrow cells
- No secondary blood or marrow aspiration step required to access Mysenchymal cells
- No centrifuge or additional equipment necessary to prepare plasma or aspirate
- Compared to traditional microfracture and k-wire stimulation, NanoFx showed superior bone marrow access with multiple trabecular access channels extending 9mm into subchondral bone1
Anika products may not be available in all geographies. Product availability is subject to the regulatory clearances in individual markets. Please reach out to your local representative or Contact Us if you have questions about specific market approvals.
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Hyalofast
Hyalofast® is a biodegradable, non-woven scaffold composed of HYAFF® (benzyl ester of hyaluronic acid) intended as support for the entrapment of mesenchymal stem cells (MSC) for the repair of chondral and osteochondral lesions. It acts as a support for bone marrow aspirate (BMA), bone marrow aspirate concentrate (BMAC), or as a chondroprotective coverage which favors in situ residence of mesenchymal stem cells after their mobilization following bone marrow stimulation procedures.
Hyalofast fibers favor cell adhesion, allowing MSC arrangement inside the three-dimensional matrix. Once implanted, it fills the defect and temporarily substitutes the chondral and osteochondral tissue in the lesion until it is absorbed and replaced by the cartilage tissue. As the HYAFF fibers degrade, the polymer releases the parent molecule enriching the implantation site with hyaluronic acid, a naturally occurring extracellular matrix molecule and a major component of human cartilage.
The unique handling properties of Hyalofast make it quickly and easily implantable via arthroscopy or mini-arthrotomy. The soft texture allows it to conform easily to the lesion anatomy. It readily adheres to the site of application without requiring additional fixation in most cases. The scaffold can be applied in any orientation or stacked due to its uniform single-layer 3D structure.
Hyalofast has been clinically demonstrated to be safe and effective in medium-to-long-term follow-up of 8 years in the repair of ankle, knee or hip chondral and osteochondral lesions, permitting the filling of the lesion with a high volume of new hyaline-like cartilage tissue, and smooth integration with the surrounding cartilage. Patients reported reduction in pain and good functional improvement of the affected injured joint, thus enabling return to their daily/non-impact sport activities with substantial pain relief and high satisfaction.
